Peer reviewed publications only  (* student authors)

52. V.V.Krishnan, I.H. Khan and P.A. Luciw, Biomarker detection and molecular profiling by multiplex microbead suspension array bead immunoproteomics, Molecular analysis and Genome Discovery (in press).

51. A.J. Wyrobek, C.F.Manohar*, V.V.Krishnan* et al., Low dose radiation response curves, networks and pathways in human lymphoblastoid cells exposed from 1 to 10cGy of acute gamma radiation. Mutation Research 722, 119-130 (2011). (* Equal contribution).

50. R. Ravindran, I.H. Khan, V.V. Krishnan et al., Multivariate analysis of large volume multiplex serodection in mouse model for infectious disease. Journal of Immunological Methods 363, 51-9 (2011).

49. J. Yamada , J.L.Phillips*, E.L. Lau, V.V. Krishnan et al., A bimodal distribution of two distinct categories of intrinsically-disordered structures with separate functions in FG nucleoporins. Mol Cell Proteomics, 9, 2205-2224 (2010).

48. E. Reese* and V.V. Krishnan, Classification of DNA sequences from thermal melting profiles, Bioinformation , 4, 463-467 (2010).

47. V.V. Krishnan and Y. Yeh,  Structure and function of Antifreeze Glycoproteins in "Antifreeze Proteins", Ed. S. Greather (in press)

46. V.V. Krishnan, I.H. Khan and P.A. Luciw, Multiplexed immunoassays by flow cytometry for molecular profiling: Basic concepts and proteomic applications, Critical Reviews in Biotechnology  29, 29-43 (2009).

45. I.H. Khan, V.V. Krishnan, M.Ziman, K. Janatpour, T.Wun, P.A. Luciw and J. Tuscano, Comparison of multiplex array large-panel kits for profiling cytokines and chemokines in rheumatoid arthritis patients, Cytometry B 3, 159-168 (2009). Journal Cover Article

44. S.P. Mielke and V.V. Krishnan,  Characterization of Protein secondary structure from NMR chemical shifts, Progress in Nuclear Magnetic Resonance Spectroscopy 54, 141-165 (2009).

43. Krishnan, V. V., E. Y. Lau, D. P. Denning, S. S. Patel, J. Yamada, M. E. Colvin and M. Rexach. Intra-molecular cohesion of coils mediated by clusters of phenylalanine-glycine motifs in the natively unfolded domain of a nucleoporin. PLOS Computational Biology, 4(8) e10000145, (2008).

42. E.Y. Lau and V.V.Krishnan, Temperature dependence of protein hydration hydrodynamics by molecular dynamics simulations, Biophysical Chemist1ry 130, 55-64, (2007).

41. V.V. Krishnan, Homonuclear NMR experiments for screening of potential drug molecules, The ViPLOK Journal, 1, 1-14 (2007).

40. S.P. Mielke and V.V. Krishnan, Superhelical denaturation of DNA: A theoretical perspective, Trends in Chemical Physics 13, 29-40 (2007).

39. Q.Z. Li, Y. Yeh, J.J. Liu*, R.E. Feeney and V.V.Krishnan, Adsorption kinetic model for thermal hysteresis activity in antifreeze proteins, Journal of Chemical Physics 124, 204702-12 (2006).

38. V.V. Krishnan, Evaluation of radiation damping effects in micro-coil NMR probes. Journal of Magnetic Resonance, 179, 294-298 (2006).

2005 and before

37. S.P. Mielke* and V.V. Krishnan, Estimation of protein secondary structure content directly from NMR spectra using an improved empirical correlation with averaged chemical shift. Journal of Structural and Functional Genomics 6, 281-285 (2005).

36. V.V. Krishnan, Saturation transfer difference (STD) NMR spectroscopy for ligand screening. Current Analytical Chemistry, 1, 307-320 (2005).

35. V.V. Krishnan, E.Y. Lau, N.M.Tsvetkova, R.E. Feeney, W.H. Fink and Y. Yeh, Characterization of the restricted rotation of the dimethyl groups in chemically N-terminal 13C labeled Antifreeze Glycoproteins: A temperature dependent study in water to ice through supercooled state.  Journal of Chemical Physics, 123, 044702 (2005).

34. S.P. Mielke*, N.J. Neilson, V.V. Krishnan, W.H. Fink and C.Benham. Brownian dynamics simulations of sequence dependent duplex denaturation in dynamically superhelical DNA.  Journal of Chemical Physics, 123, Article number: 124911 (2005).

33. S.P. Mielke* and V.V. Krishnan. An evaluation of chemical-shift based secondary structure determination in proteins: Influence of random-coil chemical shifts. Journal of Biomolecular NMR, 30, 143-153 (2004).

32. S.P. Mielke*, V.V. Krishnan, N.J. Neilson, C.Benham and W.H. Fink. Brownian dynamics simulation of DNA supercoiling and twin-supercoiling.  Journal of Chemical Physics, 121, 8104-8122 (2004).

31. V.V. Krishnan, W.H. Fink, R.E.Feeney and Y.Yeh. Translational dynamics of Antifreeze Glycoproteins in supercooled water. Biophysical Chemistry, 110, 223-230 (2004).

30. S.P. Mielke* and V.V. Krishnan. Determination of protein structure class directly from the NMR spectra using averaged chemical shifts. Bioinformatics 19, 2054-2064 (2003).

29. N. Murali and V.V. Krishnan. A primer in nuclear magnetic relaxation in liquids. Concepts in Magnetic Resonance 17, 86-116, (2003).

28. A. Sibley*, M. Cosman, and V.V. Krishnan. An empirical correlation between averaged chemical shifts and secondary structure content in proteins.  Biophysical Journal, 84, 1223-1227 (2003).

27. M. Cosman, F.C. Lightstone, V.V. Krishnan and L. Zeller, D.Roe and R. Balhorn. Screening mixtures of small molecules for binding to multiple sites on the surface of tetanus toxin C fragment by bioaffinity NMR. Chemical Research in Toxicology, 15, 1218-1228, (2002).

26. J. A. George*, M.E. Colvin and V.V. Krishnan. A simulator for ensemble quantum computing. Computer Physics Communications, 144, 277-283 (2002).

25. N. M. Tsvetkova, B. L. Phillips, V.V. Krishnan, R. E. Feeney, W.H. Fink, J.H. Crowe, S.H. Risbud, F. Tablin  and Y. Yeh. Dynamics of antifreeze glycoprotein (AFGP) in the presence of ice. Biophysical Journal, 82, 464-73 (2002).

24. M. Mesleh*, N. Belmar, C.W. Lu, V.V. Krishnan, R.S. Maxwell, C.P. Genain and M. Cosman. Marmoset fine B-cell and T-cell epitope specificities mapped onto a homology model of the extracellular domain of human myelin oligodendrocyte glycoprotein reveals potential sites of antibody binding. Nurobiology of Disease 9, 160-172 (2002).

23. V.V. Krishnan. K.H. Thornton, M.P. Thelan and M. Cosman. Solution structure and backbone dynamics of BRCT domain of human DNA ligase IIIa. Biochemistry, 40, 13158-66 (2001).

22. V.V.Krishnan. Estimation of the actual time cost of ensemble quantum computing. Physics Letters A, 291, 27-33 (2001).

21. K. Brown, B.E. Hingerty, E.A. Guenther, V.V.Krishnan, S. Broyde, K.W. Turteltaub and M. Cosman. Solution structure of the 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine C8-deoxyguanosine adduct in duplex DNA. Proceedings of the National Academy of Sciences USA, 98, 8507-8512 (2001).

20. K.H. Thornton, V.V.Krishnan, M.G. West, J. Popham*, M. Ramirez, M.P. Thelan and M. Cosman. Expression, purification and biophysical characterization of the BRCT domain of human DNA ligase IIIa. Protein Expres­sion and Purification, 21, 401-411 (2001).

19. V.V. Krishnan and M. Cosman. Novel relaxation compensated method to measure proton exchange rates in biomolecules based on decorrelation of heteronuclear two-spin order. Magnetic Resonance in Chemistry, 38, 789-794 (2000).

18. V.V.Krishnan, M. Sukumar, L.M. Gierasch and M. Cosman. Dynamics of cellular retinoic acid binding protein I on multiple time scales with implications for ligand binding. Biochemistry, 39, 9119-9129 (2000).

17. C.P. Genain, K.H. Thornton, V.V. Krishnan, M.F. Mesleh, and M. Cosman. Structural plasticity of a protein antigen implicated in the immunopathogenesis of multiple sclerosis, Annals of Neurology, 46, 936-938 (1999).

16. V.V.Krishnan, K.H. Thornton and M Cosman. An improved experimental scheme to measure self-diffusion coefficients of biomolecules with an advantageous use of radiation damping. Chemical Physics Letters, 302, 317-323 (1999).

15. V.V.Krishnan. Radiation damping: Suryan's line broadening revisited in high-resolution solution NMR. Current Science, 74, 1049-1053 (1998)

14. V.V.Krishnan and M. Cosman. An empirical relationship between rotational correlation time and solvent accessible surface area. Journal of Biomolecular NMR, 12, 177-182 (1998).

13. M.R. Hileman*, B. S. Chapman, S. Rabizadeh, V.V. Krishnan, and et al., A cytoplasmic peptide of the neurotrophin receptor p75NTR: Induction of apoptosis and NMR determined helical conformation. FEBS Letters, 415, 145-154 (1997).

12. V.V.Krishnan. Determination of oligomeric state of proteins in solution from pulsed-field-gradient self-diffusion coefficient mea­surements. A comparison of experimental, theoretical and hard-sphere approximated values. Journal of Magnetic Resonance, 124, 468-473 (1997).

11. V.V.Krishnan and M. Rance. Calculation of coherence-transfer behavior under planar versus isotropic mixing Hamiltonians and application to het­eronuclear J cross polarization experiments in solution-state NMR spectroscopy. Journal of Magnetic Resonance, 124, 205-209 (1997).

10. T. Gaal, W. Ross, E.E. Blatter, H. Tang, X. Jia, V.V. Krishnan, et al., DNA binding determinants of the a subunit of RNA Polymerase: A novel DNA binding domain architecture. Genes & Development 10, 16-26 (1996).

9. V.V.Krishnan and M. Rance. Influence of chemical exchange among the homonuclear spins in heteronuclear polarization transfer experiments in liquids. Journal of Magnetic Resonance, Series A 116, 97-106 (1995).

8. S.C. Shekar and V.V.Krishnan. Explicit formulae for MQ-filtered COSY of an arbitrary number of magnetically equivalent sets of spin-1/2 nuclei.  Magnetic Resonance in Chemistry, 31, 523-528 (1993).

7. V.V. Krishnan and Anil Kumar. Nuclear Overhauser effect in coupled spin systems using selective perturbation. Concepts in Magnetic Resonance, 4, 245-268 (1992).

6. J. Boyd, U. Hommel and V.V. Krishnan. Influence of cross-correlation between dipolar and chemical shift anisotropy relaxation mechanisms upon the trans­verse relaxation rates of 15N in macromolecules. Chemical Physics Letters, 187, 317-324 (1991).

5. V.V. Krishnan, S.C. Shekar and Anil Kumar. Simultaneous observation of positive and negative NOE in biomolecules: A bistable jump model for segmental mo­tion with modulation of internuclear distances. Journal of American Chemical Society. 113, 7542-7550 (1991).

4. V.V. Krishnan, U. Hegde and Anil Kumar. Spin diffusion in biomolecules: Effect of higher order diffusive terms in the transient NOE experiments. Journal of Magnetic Resonance, 94, 605-611 (1991).

3. V.V.Krishnan and Anil Kumar. Dipolar cross correlation effects in the nuclear Overhauser experiments of weakly and strongly coupled spins. Journal of Magnetic Resonance, 92, 293-311 (1991).

2. V.V. Krishnan, N. Murali and Anil Kumar. A diffusion equation approach to spin diffusion in biomolecules. Journal of Magnetic Resonance, 84, 255-267 (1989).

1. V.V. Krishnan, S. Raghothama and Anil Kumar. Strong coupling and flip-angle dependence of coupling patterns in heteronuclear shift correlation two-dimensional NMR spectra. Journal of Magnetic Resonance, 79, 328-335 (1988)

Last update December 2008